The MPX combines different imaging techniques in one easy-to-use and portable device: non-linear MP (two-photon, SHG & THG) and widefield epi-fluorescence and fluorescence lifetime imaging to maximize informational content, ranging from single cells up to living animals.
Dr. Christian Stirnimann
During the UPM annual conference Dr.Christian Stirnimann, ETH Zurich NEXUS, presented a case example of patient-derived liver cancer organoid drug response screening. The workflow is done with automation and in 1536 well-format with proven reproducibility.
See how 3D cell culture assay is automated with PerkinElmer JANUS® G3 Liquid Handling Workstation. GrowDex® hydrogel and cells are distributed to 384 well plate and media is added on top of the hydrogel
BioAssemblyBot (#WeCallHerBAB) empowers the freedom to design and automate organoid/spheroid models and assays.
From Advanced Solutions
We present on how we have applied the low-input MANTIS® to automate the plating of organoids, reducing requirements for expensive reagents, making organoid culture amenable to high-throughput applications.
The liquid-handling power of SPT Labtech's dragonfly discovery and Corning's Matrigel® matrix for organoid culture, to automate a forskolin-induced swelling assay of human intestinal organoids.
The new Organoid Innovation Center at Molecular Devices combines cutting-edge technologies with novel 3D biology methods to address key challenges of scaling complex 3D biology.
Discover a smart imaging system that simplifies your workflow,
enabling rapid detection and automated sequential low-to-high magnification
imaging of 3D objects.
The Pu·MA System is a benchtop device which can perform automated 3D cell based assays at the touch of the screen. Central to the system are our proprietary flowchips. Automated “hands-off” reagent exchanges take place within them.
Renner H, Grabos M, Becker KJ, Kagermeier TE, Wu J, Otto M, Peischard S, Zeuschner D, TsyTsyura Y, Disse P, Klingauf J, Leidel SA, Seebohm G, Schöler HR, Bruder JM. A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids. Elife. 2020 Nov 3;9:e52904. doi: 10.7554/eLife.52904. PMID: 33138918; PMCID: PMC7609049.
Automated 3D Cell Culture and Screening by Imaging and Flow Cytometry
Combining Automated Organoid Workflows with Artificial Intelligence-Based Analyses: Opportunities to Build a New Generation of Interdisciplinary High-Throughput Screens for Parkinson's Disease and Beyond
For over a decade Flexible Lab Solutions have built and supported advanced, innovative modular systems to suit our customers evolving needs.
Systems can be integrated into benchtop format for install on existing laboratory furniture, or designed to be housed in the Smartcel-2 automation workcell.
We'd be very pleased to discuss your organoid and 3D cell biology applications.
Look forward to hearing from you soon.
Round up of the latest technology and research
The Incucyte® Organoid Assay uses an established protocol and purpose-built software, for continuous acquisition and objective analysis of organoid size, count and morphology in a microplate format all from inside your incubator.