W8: Lab weighing and sorting for organoids and spheroids.
The W8 from Celldynamics: What if a simple label-free Biophysical characterization and sorting, performed with preserved viability, can highlight biological events in 3D Cell models?
From quality control to drug activity effect, from compactness-related data to highlighting permeation, the W8 represents a novel approach to cover worldwide claimed scientific gaps related to the need for improvements in 3D cell cultures.
Uniformity and standardization, as well as growth monitoring and protocol modifications effects, have been challenging for researchers. The W8 not only gives new perspectives on such aspects, but it does so label-free, with preserved sterility and viability and allowing a unique biophysical-based sorting of the subpopulation suitable to continue your workflow.
Many have already crossed to state of the art, would you join too?
"We’ve previously used spheroid size as a measure of cell growth under different conditions, but this doesn’t account for cell density so simply isn’t as accurate. The W8 is the first machine that allows us to properly assess how our culture conditions, drugs or different cell lines really impact on the growth of our ‘mini tumours’. The W8 is so much quicker and easier to use than our previous approach of manually sizing our spheroids, and we can even sort them for downstream analysis. We think the W8 is going to be a game-changer for our brain cancer research projects". University of Leeds, UK.
"We have generated organoids from different GEMMs of prostate cancer and observed a plethora of different structures in the cultures system. The W8 has allowed us to associate their density and weights. We have then correlated these physical parameters with different status of aggressiveness of the cancer. The W8 is precise instrumentation that will certainly change how we look into new parameters that will allow us to better define the cancer". University Of Bern, Switzerland.
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Celldynamics aims to set a new standard for in vitro testing in the pharmaceutical and biotechnology sectors with solutions designed for 3D cell models helping decision making through more reliable results.
Designed by engineers, intended for researchers.
The W8 is conceived to perform the biophysical characterization of 3D cellular models, in terms of mass density, weight, and size. All that in a small, easy-to-use, and plug & play analytical tool.
CELLENION a BICO Company.
spheroONE® Automated sorting and isolation of single spheroids and organoids.
spheroONE is an innovative single large-particle sorter and dispenser which revolutionizes 3D cellular models handling. Using precision dispensing technology together with advanced image-based sorting capabilities, spheroONE is the perfect platform for the selection and isolation of single spheroids, organoids and tumoroids. It is a game-changer in drug screening and other applications where standard 3D models will gradually replace traditional animal models.
Benefits of spheroONE® include:
- Up to 100% accurate automated isolation of single cellular aggregates using morphology and fluorescence-based sorting.
- All particles from 50 – 600 µm in diameter.
- Gentle dispensing technology maintains integrity and viability of fragile organoids.
- Biomass per well under precise control in account of user-defined number of spheroids per well and highly homogeneous populations.
- Remove cellular debris to facilitate imaging and enhance drug screening results.
- Compatible with any standard multiwell plate (i.e. 96, 384) and custom-designed labware.
- Direct visual inspection of sample with full image record of the isolated cellular aggregates.
Want to see it in action? Book a demo through spheroONE® image right.
